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Laparoscopic versus open surgery for pheochromocytoma: a meta-analysis
Sheng-Qiang Fu1, Si-Yuan Wang1, Qiang Chen1
1Department of Urology, the First Affiliated Hospital of Nanchang University, Nanchang, 330000, Jiangxi Province, China.
BMC Surgery
|July 27, 2020
Summary
Laparoscopic surgery (LS) for pheochromocytoma (PHEO) is safe and effective, leading to less intraoperative haemodynamic instability and faster recovery compared to open surgery (OS). This approach offers comparable outcomes for hypertension cure with improved patient recovery.
Area of Science:
- Endocrinology
- Surgical Oncology
- Minimally Invasive Surgery
Background:
- Pheochromocytoma (PHEO) surgical resection is standard treatment.
- Laparoscopic surgery (LS) for PHEO is debated due to pneumoperitoneum effects and tumor complexity.
- Open surgery (OS) is established but may be less optimal.
Purpose of the Study:
- Compare treatment outcomes of LS versus OS for PHEO.
- Evaluate safety and efficacy of LS in PHEO resection.
- Analyze hemodynamic stability and recovery metrics.
Main Methods:
- Systematic literature search up to November 11, 2019.
- Meta-analysis of 14 studies comparing LS and OS for PHEO.
- Quality assessment using the Newcastle-Ottawa scale.
Main Results:
- LS showed lower intraoperative haemodynamic instability (IHD) [OR=0.61].
- LS resulted in significantly less blood loss [WMD=-115.27ml] and lower transfusion rates [OR=0.33].
- Patients undergoing LS experienced earlier ambulation, food intake, shorter drainage time, and reduced hospital stay.
Conclusions:
- Laparoscopic surgery (LS) is a safe and effective option for PHEO resection.
- LS leads to reduced intraoperative haemodynamic instability (IHD) compared to open surgery (OS).
- LS offers a faster and better postoperative recovery with comparable hypertension cure rates.

