Resting-state abnormalities of posterior cingulate in autism spectrum disorder

The posterior cingulate cortex (PCC) plays pivotal roles in cognitive, social and emotional processing, as well as early neural development that supports complex interactions among different neural networks. Alterations in its local and long-range connectivity during resting state are often implicated in neuropathology of neurodevelopmental disorders such as autism spectrum disorder (ASD). ASD is characterized by social and communication deficits, as well as restricted and repetitive behaviors and interests. Individuals with ASD demonstrate persistent disturbances in cognitive and social-emotional functioning, and their PCC exhibits both local and long-range resting state abnormalities compared to typically developing healthy controls. In terms of regional metrics, only the dorsal part of the PCC showed local underconnectivity. As to long-range connectivity measures, the most replicated finding in ASD studies is the reduced functional coupling between the PCC and medial prefrontal cortex (MPFC), which may represent a core neuropathology of ASD unrelated to medication effects. Functional importance of these resting state abnormalities to ASD and directions of future study are discussed at the end of this chapter.