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Updated: Dec 13, 2025
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
Diagnostic value of circulating microRNA-208a in differentiation of preserved from reduced ejection fraction heart
Dong-Mei Li1, Bin-Xin Li2, Li-Jie Yang3
1Department of Physical Diagnosis, The Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang 157000, China.
Background:
There is no satisfactory answer on the specific biomarker that might be used in differentiating heart failure with reduced EF (HFrEF), allowing for inadequacy of N-terminal prohormone brain natriuretic peptide (NT-proBNP).
Objectives:
We aim to evaluate the value of microRNA-208a in diagnosing HFrEF patients.
Methods:
We included 120 HF patients and 60 healthy volunteers. Diagnostic values of NT-proBNP and miR-208a for HF patients versus controls and HFrEF versus HFpEF were described by area under curve (AUC), sensitivity and specificity.
Results:
HFrEF patients had significantly higher miR-208a level (p<0.001). As for diagnosing HFrEF patients, additional use of miR-208a and NT-proBNP yielded a significantly higher AUC than NT-proBNP alone (0.83, 95% CI 0.76-0.90 vs. 0.73, 95% CI 0.64-0.82) and the sensitivity and specificity were raised to 68.0% and 90.2%.
Conclusion:
Use of miR-208a in combination with NT-proBNP may allow a more reliable method in diagnosing HFrEF patients.
