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Related Experiment Video

Updated: Dec 13, 2025

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[Tryptase: A practical guide for the physician].

H Lobbes1, Q Reynaud2, S Mainbourg2

  • 1Service de Médecine Interne, Hôpital Estaing, CHU de Clermont-Ferrand, 1 Place Lucie et Raymond Aubrac, 63000 Clermont-Ferrand, France; Service de Médecine Interne et Vasculaire, Hôpital Lyon Sud, Hospices Civils de Lyon, 165 Chemin du grand Revoyet, 69310 Pierre-Bénite, France.

La Revue De Medecine Interne
|July 27, 2020
PubMed
Summary
This summary is machine-generated.

Serum tryptase levels are key indicators for diagnosing mast cell disorders like systemic mastocytosis (SM) and mast cell activation syndrome (MCAS). Understanding normal ranges and diagnostic thresholds is crucial for accurate patient assessment.

Keywords:
AnaphylaxieAnaphylaxisMast cell activation syndromeMast cellsMastocyteMastocytose systémiqueSyndrome d'activation mastocytaireSystemic mastocytosisTryptase

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Area of Science:

  • Biochemistry
  • Immunology
  • Hematology

Background:

  • Tryptase is a primary enzyme released during mast cell degranulation.
  • It plays a role in both pro-inflammatory and anti-inflammatory pathways.
  • Normal serum tryptase levels range from 0 to 11.4 μg/L.

Purpose of the Study:

  • To highlight the diagnostic utility of serum tryptase.
  • To define tryptase thresholds for specific mast cell disorders.
  • To discuss factors influencing tryptase levels.

Main Methods:

  • Review of diagnostic criteria for systemic mastocytosis (SM) and mast cell activation syndrome (MCAS).
  • Analysis of serum tryptase levels in relation to mast cell burden and clinical presentation.
  • Consideration of anaphylaxis as a hypersensitivity reaction linked to mast cells.

Main Results:

  • Elevated serum tryptase (>20 μg/L) is a criterion for SM diagnosis.
  • MCAS diagnosis involves a significant tryptase increase (20% + 2 μg/L) from baseline.
  • Tryptase levels correlate with bone marrow mast cell burden in SM.

Conclusions:

  • Serum tryptase is a vital biomarker for diagnosing mast cell disorders.
  • Specific tryptase thresholds aid in differentiating conditions like SM and MCAS.
  • Physicians must consider various physiological and pathological states affecting tryptase levels.