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Updated: Dec 13, 2025
09:19
In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
Published on: May 24, 2020
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COVID-19 infection and thrombosis
Swati Srivastava1, Iti Garg1, Anju Bansal1
1Genomics Group, Defence Institute of Physiology and Allied Science, Lucknow Road, Timarpur, Delhi 110054, India.
Summary
COVID-19 infection can cause dangerous blood clots due to inflammation and coagulation issues. Monitoring clotting factors and using anticoagulants can help prevent and treat thrombosis in patients.
Area of Science:
- Infectious Diseases
- Hematology
- Critical Care Medicine
Background:
- COVID-19, caused by SARS-CoV-2, is linked to abnormal blood clot formation.
- Viral infection triggers inflammation, endothelial damage, and coagulation cascade dysfunction.
- This can lead to disseminated intravascular coagulation (DIC) and coagulopathy, increasing thrombosis risk.
Discussion:
- This report synthesizes research on COVID-19-associated thrombosis and therapeutic strategies.
- It reviews studies on coagulopathy, elevated D-dimer, fibrinogen, and altered coagulation parameters (PT, PTT, platelets).
- Clinical implications for managing COVID-19 patients with clotting complications are discussed.
Key Insights:
- COVID-19 patients exhibit elevated D-dimer, FDP, and abnormal coagulation parameters.
- Thrombosis and coagulopathy are significant complications, potentially leading to mortality.
- Early screening of coagulation parameters is crucial for risk assessment.
Outlook:
- Clinicians should exercise caution when treating COVID-19 patients.
- Regular monitoring of coagulation parameters is recommended throughout treatment.
- Anticoagulant therapy serves as a thromboprophylaxis measure, requiring individualized dosing and duration.
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