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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
8.6K
DNA hydrogel-based gene editing and drug delivery systems.
Fangli Mo1, Kai Jiang1, Di Zhao1
1Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Advanced Drug Delivery Reviews
|July 27, 2020
Summary
DNA hydrogels offer precise construction for advanced materials. This review covers their development, stimuli-responsive properties, and applications in drug delivery and gene therapy.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Synthetic Biology
Background:
- Deoxyribonucleic acid (DNA) enables precise synthesis of complex 2D and 3D geometries.
- DNA hydrogels, crosslinked DNA networks, offer biocompatibility, porosity, and programmability.
- These properties make DNA hydrogels valuable for bioanalysis and biomedicine.
Purpose of the Study:
- To review recent advancements in DNA hydrogel synthesis and applications.
- To highlight DNA hydrogels in drug delivery systems.
- To explore future prospects in gene therapy and gene editing.
Main Methods:
- Introduction of physical and chemical crosslinking techniques for DNA hydrogel construction.
- Description of DNA hydrogel responses to biological and non-biological stimuli.
- Detailed examination of DNA hydrogel platforms for various drug delivery applications.
Main Results:
- DNA hydrogels can be synthesized with controlled architectures and responsive behaviors.
- Various drug delivery systems utilizing DNA hydrogels have been developed.
- Integration with gene editing tools presents novel therapeutic opportunities.
Conclusions:
- DNA hydrogels are versatile platforms with significant potential in drug delivery and regenerative medicine.
- Future research directions include combining DNA hydrogels with gene editing technologies for enhanced therapeutic outcomes.
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