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Updated: Dec 13, 2025
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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
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Non-coding RNAs in gastric cancer.
Shanshan Xie1, Yongxia Chang2, Hao Jin2
1The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China; Department of Cell Biology and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Cancer Letters
|July 27, 2020
Summary
Non-coding RNAs (ncRNAs) regulate biological processes and their dysregulation drives gastric cancer. This review explores ncRNA roles and therapeutic potential in cancer.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Non-coding RNAs (ncRNAs) are key regulators in cellular functions.
- Aberrant ncRNA expression is linked to human cancer development, particularly gastric cancer.
Purpose of the Study:
- To review the roles of various ncRNAs in gastric cancer.
- To discuss their potential as diagnostic biomarkers and therapeutic targets.
Main Methods:
- Literature review of studies on ncRNAs in gastric cancer.
- Analysis of oncogenic and tumor-suppressive functions.
- Examination of regulatory mechanisms and therapeutic strategies.
Main Results:
- lncRNAs, miRNAs, circRNAs, and piRNAs exhibit diverse roles in gastric cancer.
- These ncRNAs can act as oncogenes or tumor suppressors.
- Specific ncRNAs show potential for early detection and treatment.
Conclusions:
- ncRNAs are critical players in gastric cancer pathogenesis.
- Targeting ncRNAs offers promising avenues for gastric cancer therapy and diagnostics.
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