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Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver-Update

Christoph F Dietrich1, Christian Pállson Nolsøe2, Richard G Barr3

  • 1Department Allgemeine Innere Medizin (DAIM), Kliniken Hirslanden Beau Site, Salem und Permanence, Bern, Switzerland; Johann Wolfgang Goethe Universitätsklinik, Frankfurt, Germany.

Ultrasound in Medicine & Biology
|July 28, 2020
PubMed

Insights

Updated guidelines provide international recommendations for using contrast-enhanced ultrasound (CEUS) in liver applications. These guidelines clarify contrast agent differences and handling for improved patient management.

Area of Science:

  • Medical Imaging
  • Hepatology
  • Radiology

Background:

  • The European Federation of Societies for Ultrasound in Medicine and Biology first issued guidelines for hepatic contrast-enhanced ultrasound in 2004.
  • Previous guideline updates addressed changes in contrast agents and expanded to non-hepatic applications.
  • The 2012 guidelines required updating due to imprecise descriptions of contrast agents, phases, and handling, and the emergence of new evidence.

Purpose of the Study:

  • To present the fourth iteration of recommendations for the hepatic use of contrast-enhanced ultrasound (CEUS).
  • To update guidelines based on new evidence, recent developments in contrast agents, and international experience.
  • To establish standard international protocols for UCAs in liver applications to enhance patient management.

Main Methods:

  • Review and synthesis of the latest scientific evidence on contrast agents for ultrasound.
  • Incorporation of recent developments, including FDA approvals and Asian clinical experience.
  • Development of updated recommendations for the hepatic use of ultrasound contrast agents (UCAs).

Main Results:

  • The updated guidelines provide a clear distinction between different contrast agents.
  • Recommendations now include precise details on contrast phases and handling procedures.
  • The guidelines reflect an international perspective, incorporating global data and experiences.

Conclusions:

  • These updated guidelines offer a comprehensive framework for the international use of UCAs in liver applications.
  • Standardized protocols aim to improve diagnostic accuracy and patient care in hepatic imaging.
  • The document serves as a crucial resource for clinicians utilizing CEUS in liver disease management.

Keywords:
Contrast-enhanced ultrasoundGuidelineLiverWorld Federation for Ultrasound in Medicine and Biology

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