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Serum Elabela Levels Are Elevated in Patients with Hyperthyroidism.

Mahmut Buyuksimsek1, Erdinc Gulumsek2, Muhammed Zubeyir Aslan3

  • 1Department of Medical Oncology, University of Health Sciences-Adana Health Practice and Research Center.

The Tohoku Journal of Experimental Medicine
|July 28, 2020
PubMed
Summary

Serum elabela levels are elevated in hyperthyroidism, particularly in patients with co-existing hypertension. This finding suggests elabela may play a role in managing cardiovascular issues associated with hyperthyroidism and hypertension.

Keywords:
apelinergic systemelabelahypertensionhyperthyroidismsystolic blood pressure

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Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Peptide Signaling

Background:

  • The apelinergic system, involving apelin peptide and APJ receptor, modulates cardiovascular function.
  • Apelin and elabela (toddler) are peptide ligands with similar cardiovascular effects like vasodilation and increased contractility.
  • Serum elabela levels in hyperthyroidism are not well-characterized.

Purpose of the Study:

  • To investigate serum elabela levels in patients with newly diagnosed Graves' disease hyperthyroidism.
  • To examine the association between serum elabela levels and hypertension in these patients.

Main Methods:

  • Cross-sectional study of 74 hyperthyroid patients and 20 healthy controls.
  • Serum elabela levels measured using enzyme-linked immunosorbent assay (ELISA).
  • Patients categorized into hyperthyroid without hypertension and hyperthyroid with hypertension groups.

Main Results:

  • Hyperthyroid patients exhibited higher basal heart rate, serum glucose, and hs-CRP compared to controls.
  • Serum elabela levels were significantly higher in hyperthyroid patients versus controls.
  • Elevated serum elabela levels were more pronounced in hyperthyroid patients with hypertension.

Conclusions:

  • Serum elabela levels are significantly increased in hyperthyroidism, especially when hypertension is present.
  • Serum elabela levels correlate with systolic blood pressure.
  • Increased elabela may offer protective cardiovascular effects in hyperthyroidism and hypertension.