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Mean Platelet Volume/Lymphocyte Ratio as a Prognostic Indicator for HBV-Related Decompensated Cirrhosis

JianPing Wu1, WeiLin Mao1, XinKe Li2

  • 1Department of Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.

Gastroenterology Research and Practice
|July 28, 2020
PubMed

Insights

The mean platelet volume/lymphocyte ratio (MPVLR) can predict mortality in patients with hepatitis B virus-related decompensated cirrhosis (HBV-DeCi). Higher MPVLR indicates a poorer prognosis and increased risk of death.

Area of Science:

  • Hepatology
  • Internal Medicine
  • Clinical Pathology

Background:

  • Hepatitis B virus-related decompensated cirrhosis (HBV-DeCi) is a severe liver condition with significant mortality.
  • Accurate prognostic markers are crucial for managing patients with HBV-DeCi.

Purpose of the Study:

  • To investigate the prognostic value of the mean platelet volume/lymphocyte ratio (MPVLR) in predicting mortality among patients with HBV-DeCi.
  • To determine if MPVLR can serve as an independent predictor of short-term mortality in this patient cohort.

Main Methods:

  • Retrospective review of medical records for 101 patients diagnosed with HBV-DeCi.
  • Extraction of baseline clinical and laboratory data, including MPVLR.
  • Analysis of MPVLR's predictive value for death using receiver operating characteristic (ROC) curve analysis and multivariate logistic regression.

Main Results:

  • Patients with a high MPVLR group showed significantly higher 90-day mortality compared to those in the low MPVLR group.
  • MPVLR was identified as an independent predictor of 90-day mortality in patients with HBV-DeCi.
  • The study demonstrated a clear association between elevated MPVLR and increased mortality risk.

Conclusions:

  • An elevated MPVLR is associated with adverse outcomes and increased mortality in patients with HBV-DeCi.
  • MPVLR may be a valuable biomarker for risk stratification and could be incorporated into future prognostic scoring systems for HBV-DeCi.
Abstract

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