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Related Experiment Video

Updated: Dec 13, 2025

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Endophthalmitis resulting from gonococcal keratoconjunctivitis.

R Bollam1, M Yassin1, T Phan2

  • 1Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

New Microbes and New Infections
|July 28, 2020
PubMed
Summary
This summary is machine-generated.

Neisseria gonorrhoeae, a common cause of sexually transmitted infections, can rarely cause severe ocular disease. This case highlights gonococcal keratoconjunctivitis leading to endophthalmitis, even without proven sexual transmission.

Keywords:
EndophthalmitisNeisseria gonorrhoeaegram-negative diplococcikeratoconjunctivitispreseptal cellulitis

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Neisseria gonorrhoeae is a significant global pathogen responsible for widespread morbidity.
  • While commonly associated with sexually transmitted infections, ocular involvement is infrequent.
  • Gonococcal ocular infections can progress to severe complications like ulcerative keratitis and corneal perforation.

Observation:

  • A rare case of endophthalmitis secondary to gonococcal keratoconjunctivitis is presented.
  • The patient's ocular infection developed without a definitively proven sexual transmission route.

Findings:

  • Gonococcal keratoconjunctivitis can progress to endophthalmitis, a serious intraocular infection.
  • The bacterium Neisseria gonorrhoeae demonstrated potential for causing severe ocular disease beyond typical presentations.

Implications:

  • This case underscores the importance of considering Neisseria gonorrhoeae in severe ocular infections, irrespective of typical transmission routes.
  • Early diagnosis and treatment are crucial to prevent vision loss from gonococcal-induced endophthalmitis.