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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
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Biliary Microbiota and Bile Acid Composition in Cholelithiasis.
Vyacheslav A Petrov1, María A Fernández-Peralbo2, Rico Derks3
1Central Research Laboratory, Siberian State Medical University, Tomsk, Russia.
Biomed Research International
|July 28, 2020
Summary
Bile acids and gut microbiota interact, influencing bile microbial communities in gallstone patients. Increased taurocholic and taurochenodeoxycholic acids correlate with microbial diversity and opportunistic pathogens.
Area of Science:
- Microbiology
- Gastroenterology
- Biochemistry
Background:
- The interplay between bile acids (BAs) and gut microbiota is known, but less studied in bile.
- This study investigates BA-microbiota interactions within the complex bile matrix.
Purpose of the Study:
- To analyze the associations between bile acid composition and gallbladder microbiota in patients with gallstone disease.
- To understand how Opisthorchis felineus infection status affects these interactions.
Main Methods:
- LC-MS/MS was used to measure bile acid composition in 37 gallstone patients.
- Gallbladder microbiota were analyzed using 16S rRNA gene sequencing.
- Statistical analyses identified correlations between bile acids and microbial taxa.
Main Results:
- Bile acid profiles and Opisthorchis felineus infection influenced bile microbial community diversity.
- Taurocholic acid and taurochenodeoxycholic acid concentrations correlated positively with microbial alpha-diversity.
- Specific bacterial families, genera, and species showed direct associations with these bile acids.
Conclusions:
- Significant associations exist between bile microbiota diversity, taxonomic profiles, and bile acid levels in cholelithiasis patients.
- Elevated taurochenodeoxycholic acid and taurocholic acid levels are linked to increased bile microbiota alpha-diversity and the presence of opportunistic pathogens.
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