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Updated: Dec 13, 2025
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Pulmonary involvement in systemic sclerosis: exploring cellular, genetic and epigenetic mechanisms
Bohdana Doskaliuk1,2, Liubomyr Zaiats3, Roman Yatsyshyn4
1Academician Ye. M. Neiko Department of Internal Medicine #1, Clinical Immunology and Allergology, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine. Doskaliuk_Bo@ifnmu.edu.ua.
Rheumatology International
|July 28, 2020
Summary
Systemic sclerosis (SSc) involves immune inflammation, vasculopathy, and fibrosis, often affecting the lungs. This review explores new findings in SSc-associated pulmonary disease pathophysiology and potential treatments.
Area of Science:
- Immunology and Rheumatology
- Pulmonology
- Genetics and Epigenetics
Background:
- Systemic sclerosis (SSc) is a complex autoimmune disorder.
- Pulmonary complications, including interstitial lung disease (ILD) and pulmonary hypertension (PH), significantly impact SSc patient outcomes.
- The precise mechanisms driving SSc pathogenesis and its pulmonary manifestations remain incompletely understood.
Purpose of the Study:
- To review and analyze recent advancements in understanding the pathophysiology of SSc-associated pulmonary involvement.
- To explore emerging diagnostic and therapeutic strategies for SSc-related lung disease.
- To elucidate the cellular and molecular mechanisms underlying SSc-driven ILD and PH.
Main Methods:
- Comprehensive literature review of recent research on SSc pathophysiology.
- Analysis of cellular interactions, including exosomes, microvesicles, and apoptotic bodies.
- Examination of epigenetic modifications such as non-coding RNAs, DNA methylation, and histone modifications.
Main Results:
- Identification of key cellular interactions contributing to progressive ILD and PH in SSc.
- Discussion of the role of extracellular vesicles in SSc pathogenesis.
- Highlighting the impact of epigenetic factors on SSc development and progression.
Conclusions:
- New insights into SSc pathophysiology reveal complex cellular and molecular interactions.
- Epigenetic modifications and extracellular vesicles represent promising targets for future research.
- Further investigation is crucial for developing effective diagnostic and therapeutic interventions for SSc-associated pulmonary disease.
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