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Vitamin D receptor gene polymorphism in patients with osteomalacic myopathy in Egypt
Hossam M Shokri1, Karim O Mohamed2, Nagia A Fahmy2
1Neuromuscular Research Unit, Neuropsychiatry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. hossam.shokri@med.asu.edu.eg.
Introduction:
Vitamin D works by binding to vitamin D receptor (VDR). The muscle involvement in hypovitaminosis D was broadly named osteomalacic myopathy.
Methods:
A case control study involved 20 female patients diagnosed with osteomalacic myopathy compared with 15 age-matched healthy female controls. We assessed both for VDR genotype single-nucleotide polymorphisms (SNP) at 3 sites (ApaI, BsmI, and FokI).
Results:
ApaI and BsmI genotypes distribution in both groups showed non-significant difference unlike FokI genotypes in which we found significantly higher percentages of single allele mutation in patients vs. controls.
Conclusion:
The relation of VDR gene SNPs to muscle function was studied before but in healthy subjects. We tried to correlate if presence/absence of a certain mutation is responsible for the appearance of osteomalacic myopathy.
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