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Proteinuria and statural growth
C Polito1, A La Manna, A N Olivieri
1Department of Paediatrics, 1st Faculty of Medicine and Surgery, University of Naples, Italy.
Insights
Heavy proteinuria in children can cause growth delays, especially when combined with glycosuria and chronic kidney disease. Monitoring growth is crucial for affected pediatric patients.
Area of Science:
- Pediatric Nephrology
- Growth and Development
- Renal Medicine
Background:
- Proteinuria is a common finding in pediatric kidney diseases.
- The impact of proteinuria on statural growth requires further elucidation.
- Understanding growth patterns in children with glomerulopathies is essential for clinical management.
Purpose of the Study:
- To investigate the relationship between proteinuria and statural growth in children.
- To identify risk factors associated with growth delay in pediatric glomerulopathies.
Main Methods:
- A cohort of 14 children with persistent proteinuria (>30 mg/kg/day) was followed for 1.5-4.3 years.
- Children received minimal or short-term steroid therapy.
- Growth parameters and renal function were monitored.
Main Results:
- Three patients with heavy proteinuria (>100 mg/kg/day), glycosuria, and chronic renal failure experienced significant growth delay (1-2.1 height SDS loss).
- Other patients exhibited minor growth variations.
- Heavy proteinuria, when accompanied by glycosuria and chronic renal failure, emerged as a risk factor.
Conclusions:
- Severe proteinuria, particularly when associated with glycosuria and progression to chronic renal failure, poses a significant risk for growth impairment in children.
- Early identification and management of these factors may be crucial for optimizing growth outcomes in pediatric kidney disease.
Abstract:
In order to assess the possible effects of proteinuria on statural growth, we studied 14 children with various glomerulopathies and proteinuria persistently above 30 mg/kg/day which were followed-up for 1.5-4.3 years. They had received only short-term steroid therapy or no steroids at all. During the follow-up, 3 patients lost 1-2.1 height standard deviation scores. These patients had proteinuria above 100 mg/kg/day with associated glycosuria, and they went into chronic renal failure. The other patients had minor variations of the growth curve. In our experience heavy proteinuria represents a risk factor for growth delay when it is associated with glycosuria and chronic renal failure.