Related Experiment Video
Updated: Dec 13, 2025

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
Published on: July 17, 2021
APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China
Jialin Abuzhalihan1,2, Dilare Adi1,2, Yong-Tao Wang1,2
1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, P.R. China.
Abstract:
Hyperlipidemia is one of the main risk factors for coronary artery disease (CAD). In the present study, we aimed to explore whether the single-nucleotide polymorphisms (SNPs) in amyloid precursor-like protein (APLP) 2 (APLP2) gene were associated with high lipid levels in Chinese population in Xinjiang, China. We recruited 1738 subjects (1187 men, 551 women) from the First Affiliated Hospital of Xinjiang Medical University, and genotyped three SNPs (rs2054247, rs3740881 and rs747180) of APLP2 gene in all subjects by using the improved multiplex ligation detection reaction (iMLDR) method. Our study revealed that the rs2054247 SNP was associated with serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) levels, and high-density lipoprotein cholesterol (HDL-C) in additive model (all P<0.05). The rs747180 SNP was associated with serum TC and LDL-C levels in additive model (all P<0.05). Our study revealed that both rs2054247 and rs747180 SNPs of the APLP2 gene were associated with high TC and LDL-C levels in Chinese subjects in Xinjiang.
More Related Videos
06:47Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
Published on: January 28, 2021
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Pleiotropy
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...