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Bupivacaine acute toxicity protection by diazepam in mice
B Bruguerolle1, N Emperaire, A Ottomani
1Laboratoire de Pharmacologie Médicale, Faculté de Médecine, Marseille, France.
Clinical and Experimental Pharmacology & Physiology
|July 1, 1988
Abstract:
1. The effects of acute and 8-day administration of diazepam (DZP) on the acute toxicity of bupivacaine in the mouse were studied. 2. Protection of bupivacaine-induced acute toxicity by DZP appears to be dose-dependent after treatment for 8 days but not after acute treatment.