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ent-Atisane diterpenoids: isolation, structure and bioactivity.

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Summary

This review covers ent-atisane diterpenoids, a diverse class of natural products. It summarizes their isolation, structure, and bioactivity from 1965 to 2020.

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Area of Science:

  • Natural Product Chemistry
  • Organic Chemistry
  • Medicinal Chemistry

Background:

  • Ent-atisane diterpenoids represent a large class of over 150 compounds.
  • These natural products exhibit diverse chemical structures.
  • They possess significant and valuable biological activities.

Purpose of the Study:

  • To provide a comprehensive review of ent-atisane diterpenoids.
  • To summarize their isolation from natural sources.
  • To detail their structural characteristics and bioactivities.

Main Methods:

  • Literature review covering research from 1965 to 2020.
  • Analysis of published data on isolation and structure elucidation.
  • Compilation of reported bioactivity studies.

Main Results:

  • Over 150 ent-atisane diterpenoids have been identified.
  • The synthesis of the archetypal member preceded its natural isolation.
  • Diverse bioactivities have been reported for this compound class.

Conclusions:

  • Ent-atisane diterpenoids are a well-studied class of natural products.
  • Their unique discovery history highlights synthetic and isolation efforts.
  • Continued research is warranted to explore their full potential.