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Updated: Dec 13, 2025
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Formulating and Characterizing an Exosome-based Dopamine Carrier System
Published on: April 4, 2022
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Exosomes as drug delivery systems: A brief overview and progress update
Suyash M Patil1, Shruti S Sawant1, Nitesh K Kunda1
1Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Jamaica, NY 11439, USA.
Summary
Exosomes, tiny vesicles, show promise as drug delivery systems due to their biocompatibility and targeting abilities. This review covers their biogenesis, applications in delivering various molecules, and current challenges for therapeutic use.
Area of Science:
- Biotechnology and Nanomedicine
- Cell Biology and Vesicular Transport
Background:
- Exosomes are endogenous, membrane-bound vesicles involved in intercellular communication.
- Their composition varies, influencing their biological roles and potential applications.
- Exosomes are recognized for their diagnostic biomarker potential and drug delivery capabilities.
Purpose of the Study:
- To provide an overview of exosome biogenesis, functions, and contents.
- To highlight recent advancements in utilizing exosomes for drug delivery systems.
- To discuss the challenges associated with exosome-based therapeutic strategies.
Main Methods:
- Review of literature on exosome biogenesis and characterization techniques.
- Analysis of studies employing exosomes for the delivery of small molecules, macromolecules, and nucleotides.
- Discussion of exosome separation and identification methodologies.
Main Results:
- Exosomes possess favorable properties for drug delivery, including biocompatibility, tumor homing, and stability.
- Demonstrated efficacy in delivering diverse therapeutic payloads to recipient cells.
- Progress in optimizing exosome targeting efficiency for various diseases and cancer therapy.
Conclusions:
- Exosomes represent a promising platform for advanced drug delivery systems.
- Further research is needed to overcome challenges in large-scale production and clinical translation.
- Exosomes hold significant potential for treating various diseases, particularly cancer.
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