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Updated: Dec 13, 2025

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Post-stroke depression: A 2020 updated review.

Gustavo C Medeiros¹, Durga Roy², Nicholas Kontos³

¹Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.

General Hospital Psychiatry

|July 28, 2020

Summary

This summary is machine-generated.

Post-stroke depression (PSD) affects 18-33% of stroke survivors and is underdiagnosed. Early detection and combined treatment are crucial for better recovery and quality of life.

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Area of Science:

Neuroscience
Psychiatry
Clinical Medicine

Background:

Post-stroke depression (PSD) is a prevalent complication following stroke.
PSD is linked to adverse outcomes including increased mortality, impaired recovery, cognitive deficits, and reduced quality of life.

Purpose of the Study:

To provide an updated, comprehensive, and clinically relevant review of post-stroke depression.
To examine risk factors, pathophysiology, assessment, prevention, and treatment strategies for PSD.

Main Methods:

A narrative review of literature from major databases (PubMed, Medline, EMBase, Google Scholar, Cochrane).
Prioritization of high-level evidence, including longitudinal studies, RCTs, systematic reviews, and meta-analyses.
Review of 124 articles, with 65% published since 2016.

Main Results:

PSD prevalence ranges from 18% to 33%, with significant underdiagnosis and undertreatment.
Key risk factors include female sex, prior psychiatric history, stroke characteristics (lesion location/size), recent stroke, poor social support, and disability.
Pathophysiology involves neurochemical imbalances, inflammation, HPA axis dysregulation, and excitotoxicity.

Conclusions:

Post-stroke depression is a common and treatable condition with significant negative impacts.
Effective management requires early detection and a multimodal approach combining pharmacological, psychosocial, and stroke-specific interventions.