Related Experiment Video

Updated: Dec 13, 2025

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.7K

Motor repertoire is age-inadequate in infants with cystic fibrosis

Haluk Tekerlek1, Akmer Mutlu2, Deniz Inal-Ince2

  • 1Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. haluktekerlek@gmail.com.

Pediatric Research
|July 28, 2020
PubMed

Insights

Infants with cystic fibrosis (CF) show abnormal fidgety movements (FMs) and a lower motor optimality score (MOS). MOS may predict CF disease severity and guide early intervention planning for affected infants.

Area of Science:

  • Pediatric neurology
  • Developmental pediatrics
  • Neonatology

Background:

  • General movements (GMs) in infants, specifically fidgety movements (FMs), emerge between 9 and 20 weeks postterm.
  • Cystic Fibrosis (CF) is a genetic disorder that can impact neurodevelopment.
  • Evaluating FMs and motor repertoire in infants with CF is crucial for understanding early developmental trajectories.

Purpose of the Study:

  • To assess fidgety movements (FMs) and motor repertoire in infants with cystic fibrosis (CF).
  • To investigate the relationship between motor optimality score (MOS) and clinical findings in infants with CF.
  • To explore the potential of MOS in predicting CF disease severity and informing early intervention strategies.

Main Methods:

  • Analysis of 5-minute video recordings of 18 infants with CF and 20 healthy controls (age 3-5 months postterm).
  • Utilized the Prechtl General Movement Assessment to evaluate FMs and motor repertoire.
  • Calculated the Motor Optimality Score (MOS) for all participants.

Main Results:

  • Infants with CF exhibited a significantly lower MOS compared to healthy controls (p < 0.05).
  • Fifty percent of infants with CF displayed abnormal or absent/sporadic FMs.
  • MOS showed a negative association with hospitalization duration (r = -0.378) and a positive association with vitamin A levels (r = 0.665) in CF infants.

Conclusions:

  • Lower MOS and abnormal/sporadic FMs were observed in infants with CF, indicating potential developmental challenges.
  • MOS demonstrated a correlation with clinical factors like hospitalization duration and vitamin A levels.
  • MOS may serve as a valuable tool, alongside genetic testing, for predicting CF disease severity and guiding the implementation of targeted early intervention programs.
Abstract

More Related Videos

Quantified Assessment of Infant's Gross Motor Abilities Using a Multisensor Wearable09:24

Quantified Assessment of Infant's Gross Motor Abilities Using a Multisensor Wearable

Published on: May 17, 2024

1.9K
A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

25.2K

Related Concept Videos

Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
338
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
113
Assessment of Airway, Skin Color, and Use of Accessory Muscles01:30

Assessment of Airway, Skin Color, and Use of Accessory Muscles

A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
1.4K