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3D Printing and Bioprinting Nerve Conduits for Neural Tissue Engineering
Xiaoling Yu1, Tian Zhang1,2, Yuan Li1
1School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, China.
Polymers
|July 29, 2020
Summary
3D printing and bioprinting offer promising solutions for fabricating nerve conduits to repair peripheral nerve damage. This review details materials, technologies, and future directions for advanced nerve therapies.
Area of Science:
- Biomaterials Science
- Neural Engineering
- Regenerative Medicine
Background:
- Peripheral nerve damage presents a significant clinical challenge, necessitating effective repair and replacement strategies.
- Advances in 3D printing and bioprinting technologies are revolutionizing neural engineering applications.
- Customizable nerve conduits are crucial for successful peripheral nerve regeneration.
Purpose of the Study:
- To review biomaterial inks and bioinks utilized in 3D printing and bioprinting of peripheral nerve conduits.
- To explore various 3D manufacturing technologies applicable to nerve conduit fabrication.
- To present future outlooks for 3D and 4D printing in personalized nerve therapies.
Main Methods:
- Review of literature on biomaterials (hydrogels, polyesters, composites) and bioinks for nerve conduits.
- Analysis of 3D printing techniques: extrusion, inkjet, stereolithography.
- Examination of bioprinting strategies incorporating cells, bioactive molecules, and drugs.
Main Results:
- Diverse biomaterials and bioinks are available for 3D printing nerve conduits.
- Multiple 3D printing and bioprinting technologies enable precise fabrication of nerve guidance structures.
- Integration of biological components enhances the regenerative potential of printed nerve conduits.
Conclusions:
- 3D printing and bioprinting are powerful tools for creating advanced peripheral nerve conduits.
- Material selection and printing technology are key factors for successful nerve regeneration.
- Future developments in 3D and 4D printing hold significant promise for tailored nerve repair therapies.
