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Analgesia and Pain Management

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Updated: Dec 13, 2025

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

Magnesium and Pain.

Hyun-Jung Shin¹, Hyo-Seok Na¹, Sang-Hwan Do^1,2

¹Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do 13620, Korea.

|July 29, 2020

Summary

Magnesium acts as an NMDA receptor antagonist, reducing pain hypersensitivity. This mineral shows potential as an adjuvant analgesic for various pain conditions, including neuropathic pain and migraines.

Keywords:

analgesia magnesium pain

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Area of Science:

Pharmacology
Neuroscience
Pain Management

Background:

Magnesium's antinociceptive effects are primarily mediated by antagonism of the N-methyl-D-aspartate (NMDA) receptor.
NMDA receptors play a critical role in pain signal transduction and central sensitization.

Purpose of the Study:

To review the role of magnesium in pain management.
To explore the mechanisms and clinical applications of magnesium as an analgesic.

Main Methods:

Literature review of studies investigating magnesium's effects on pain.
Analysis of magnesium's action on NMDA receptors and its impact on pain pathways.

Main Results:

Magnesium administration (oral and parenteral) can alleviate pain and reduce perioperative analgesic needs.
Beneficial effects observed in neuropathic pain (e.g., diabetic neuropathy, chemotherapy-induced neuropathy), fibromyalgia, dysmenorrhea, and headaches.
Magnesium's NMDA receptor antagonism prevents central sensitization and reduces pain hypersensitivity.

Conclusions:

Magnesium demonstrates significant potential as an adjuvant analgesic across diverse pain conditions.
Further research is needed to fully elucidate magnesium's antinociceptive mechanisms and optimize its clinical use.