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Hepatitis A susceptibility parallels high COVID-19 mortality
Faik Sarialioğlu1, Fatma Burcu Belen1, Kadir Mutlu Hayran2
1Department of Pediatric Hematology and Oncology, Faculty of Medicine, Başkent University, Ankara, Turkey
Turkish Journal of Medical Sciences
|July 29, 2020
Summary
Populations with higher susceptibility to Hepatitis A Virus (HAV) showed increased COVID-19 mortality rates. This suggests a potential link between HAV immunity and COVID-19 outcomes, warranting further investigation.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- COVID-19 emerged as a significant global health crisis.
- Hypothesized potential protective effects of Hepatitis A Virus (HAV) immunity against COVID-19.
Discussion:
- Analyzed global COVID-19 data (7.3M cases, 413K deaths) against WHO HAV susceptibility classifications.
- Investigated the correlation between HAV susceptibility and COVID-19 mortality across 213 countries.
Key Insights:
- A significant positive trend was observed between HAV susceptibility and COVID-19 mortality rates (P <0.001).
- Individuals in countries with medium/high HAV susceptibility faced a 27.8 times higher mortality risk (95% CI: 3.6–213.2).
Outlook:
- HAV susceptibility may correlate with COVID-19 mortality, independent of confounding factors.
- Further research is essential to validate these findings and understand the underlying mechanisms.
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