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Related Concept Videos

Autophagy01:27

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Glycogen: the missing link in neuronal autophagy?

Akanksha Onkar1, Deepashree Sheshadri1, Subramaniam Ganesh1

  • 1Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur , Kanpur, India.

Autophagy
|July 29, 2020
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Summary

Glycogen synthase (GYS) plays a key role in neuronal survival during cellular stress. This commentary explores the link between GYS, glycogen metabolism, and autophagy induction in neurons.

Keywords:
Glycogen metabolic pathwayglycogen synthasehypoxianeuroprotectionoxidative stress

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Area of Science:

  • Cellular biology
  • Neuroscience
  • Metabolism

Background:

  • Macroautophagy/autophagy is a cellular degradation process crucial for survival under stress.
  • The glycogen metabolic pathway is increasingly recognized for its role in neuronal survival during oxidative stress and hypoxia.
  • Recent findings suggest a connection between glycogen synthesis and the induction of autophagy.

Purpose of the Study:

  • To highlight the emerging role of glycogen synthase (GYS) in neuronal autophagy.
  • To discuss the involvement of GYS in neuronal stress response mechanisms.

Main Methods:

  • This is a commentary, not an experimental study.
  • Literature review and synthesis of recent reports.

Main Results:

  • Glycogen synthase (GYS) is identified as a significant factor in neuronal autophagy.
  • GYS activity influences neuronal survival pathways under stress conditions.

Conclusions:

  • Glycogen synthase (GYS) emerges as a critical regulator of autophagy in neurons.
  • Understanding the GYS-autophagy link offers new insights into neuronal stress resilience and potential therapeutic targets.