Pediatric Postoperative Nausea and Vomiting: Assessing the Impact of Evidence-Based Practice Change

Robert W Simon1

  • 1is a staff nurse anesthetist for the Holy Redeemer Health System in Pennsylvania and serves as Didactic Education Coordinator and faculty member for the Frank J. Tornetta School of Anesthesia at Einstein Medical Center Montgomery, Norristown, Pennsylvania.

AANA Journal
|July 29, 2020
PubMed

Insights

Documenting a child's history of postoperative nausea and vomiting (PONV) before surgery significantly reduces its occurrence. This practice change lowered PONV rates by 22% in pediatric patients.

Area of Science:

  • Anesthesiology
  • Pediatric Surgery
  • Evidence-Based Practice

Background:

  • Postoperative nausea and vomiting (PONV) is a common complication after anesthesia and surgery.
  • Children are twice as likely as adults to experience PONV.
  • Key risk factors include age over 3 years, surgery duration over 30 minutes, surgical type, and prior PONV history.

Purpose of the Study:

  • To evaluate if preoperative documentation of pediatric patients' PONV history reduces postoperative PONV rates.
  • To implement and assess an evidence-based practice change aimed at improving PONV management in children.

Main Methods:

  • A PONV history assessment tool was introduced.
  • A retrospective chart review compared PONV rates in 2,279 cases before the intervention with 2,006 cases after.
  • Data analysis focused on the impact of documented PONV history on postoperative outcomes.

Main Results:

  • A significant decrease in PONV rates was observed post-intervention (153 vs. 120 cases).
  • The overall incidence of PONV dropped by 22%.
  • This reduction was statistically significant (P = .0043) and linked to documented PONV history.

Conclusions:

  • Preoperative documentation of a patient's PONV history is effective in lowering postoperative PONV rates in pediatric populations.
  • Implementing targeted assessments for PONV history represents a successful evidence-based practice change.
  • This strategy contributes to improved patient safety and comfort following surgical procedures.

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
428
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
494
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
2.3K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
148
Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
689
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
575