Related Experiment Video

Updated: Dec 13, 2025

Author Spotlight: Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
06:04

Author Spotlight: Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

Published on: June 9, 2023

1.4K

Risk Factors for Left Ventricle Enlargement in Children With Frequent Ventricular Premature Complexes

Bo Chen1, Jiaoyu Li1, Shujing Li1

  • 1Department of Pediatric Cardiology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The American Journal of Cardiology
|July 29, 2020
PubMed

Insights

Idiopathic frequent ventricular premature complexes (VPC) can cause left ventricle enlargement in children. Right bundle branch block and high VPC burden are key risk factors, but enlargement is reversible with treatment.

Area of Science:

  • Pediatric Cardiology
  • Electrophysiology
  • Cardiovascular Imaging

Background:

  • Idiopathic frequent ventricular premature complexes (VPC) are increasingly recognized in pediatric populations.
  • Left ventricle (LV) enlargement can be a complication of frequent VPC, potentially impacting cardiac function.
  • Understanding risk factors for LV enlargement is crucial for timely intervention and management.

Purpose of the Study:

  • To identify risk factors associated with left ventricle enlargement in children experiencing idiopathic frequent VPC.
  • To analyze the clinical features and presentation of pediatric patients with frequent VPC and LV changes.
  • To discuss effective treatment strategies for frequent VPC and associated LV enlargement.

Main Methods:

  • Retrospective evaluation of pediatric patients diagnosed with idiopathic frequent VPC between 2013 and 2019.
  • Comparison of clinical data, including demographics, VPC characteristics, and LV structure, between patients with and without LV enlargement.
  • Multivariate analysis to determine independent risk factors for LV enlargement.

Main Results:

  • Patients with LV enlargement exhibited a higher VPC burden (30.2% vs 9.4%), increased prevalence of ventricular tachycardia (75.9% vs 16.4%), and more frequent couplets and trigeminy.
  • Higher QRS wave width and a greater incidence of right bundle branch block were observed in the LV enlargement group.
  • Multivariate analysis identified right bundle branch block (OR=143.9) and VPC burden >20% (OR=132.6) as significant risk factors for LV enlargement.

Conclusions:

  • Frequent VPC can lead to significant left ventricle enlargement and potential dysfunction in children.
  • Right bundle branch block and a high VPC burden are critical risk factors for developing LV enlargement.
  • Left ventricle enlargement associated with frequent VPC is often reversible following treatment, such as catheter ablation or medication.

More Related Videos

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

3.2K
Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

1.3K

Related Concept Videos

Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
215
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
2.1K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
248
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
243
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
232
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
330