Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

176
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
176
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

131
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
131
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

148
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
148
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

153
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
153
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

113
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
113

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trends in length-of-stay per total body surface area burn in pediatric patients: A report from the pediatric injury and quality improvement collaborative.

The journal of trauma and acute care surgery·2026
Same author

Impact of Delayed Inguinal Hernia Repair in Infants.

The Journal of surgical research·2025
Same author

Same Day Discharge Following Minimally Invasive Repair of Pectus Excavatum.

Journal of pediatric surgery·2025
Same author

Successful VA ECMO on an adolescent pre-B cell acute lymphoblastic leukemia patient with necrotizing fasciitis from <i>Clostridium septicum</i>.

Archive of clinical cases·2025
Same author

Switching lanes: No home antibiotics or laboratory testing prior to discharge in perforated appendicitis.

Journal of pediatric surgery·2025
Same author

Statewide Analysis of Pediatric Appendicitis Outcomes by Pediatric Surgeon Availability.

The Journal of surgical research·2025

Related Experiment Video

Updated: Dec 13, 2025

Maintenance of a Lateral Fluid Percussion Injury Device
05:16

Maintenance of a Lateral Fluid Percussion Injury Device

Published on: April 21, 2023

1.3K

Pediatric firearm injuries: A Midwest experience.

Pamela M Choi1, Charlene Dekonenko2, Pablo Aguayo2

  • 1Department of Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO 64108; LCDR, US Navy, Navy Medicine Professional Development Center.

Journal of Pediatric Surgery
|July 29, 2020
PubMed
Summary

Pediatric firearm injuries affect children and teens, with younger children experiencing more accidental shootings. Rural areas show higher rates of firearm injuries, particularly accidental ones, in children.

Keywords:
FirearmGunPediatric trauma

More Related Videos

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.2K
Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

1.3K

Related Experiment Videos

Last Updated: Dec 13, 2025

Maintenance of a Lateral Fluid Percussion Injury Device
05:16

Maintenance of a Lateral Fluid Percussion Injury Device

Published on: April 21, 2023

1.3K
Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.2K
Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

1.3K

Area of Science:

  • Pediatric Trauma
  • Public Health
  • Epidemiology

Background:

  • Firearm injuries represent a critical public health issue impacting children.
  • A Level 1 Pediatric Trauma Center analyzed its patient population experiencing firearm injuries.
  • Understanding the demographics and circumstances of pediatric firearm injuries is essential.

Purpose of the Study:

  • To define the experience of a Level 1 Pediatric Trauma Center with firearm injuries.
  • To identify the patient population affected by pediatric firearm injuries.
  • To analyze age and geographic disparities in pediatric firearm injuries.

Main Methods:

  • Retrospective review of a trauma registry from 2012 to 2017.
  • Inclusion of all pediatric patients (age ≤ 17 years) with firearm injuries.
  • Stratification by age group (≤12 and 13-17 years) and geographic location.

Main Results:

  • 236 pediatric patients were analyzed; 47.9% were ≤12 years, 52.1% were 13-17 years.
  • Younger children had higher operative intervention rates (52.2% vs. 37.2%) but similar mortality.
  • Accidental shootings and injuries by known individuals were more common in younger children; assaults by strangers were more common in older children.
  • Small cities had the highest firearm injury rates per capita, predominantly from accidental discharges, across both age groups.

Conclusions:

  • Pediatric firearm injuries are not solely an urban teen problem; young children are significantly affected.
  • Rural areas face a high burden of accidental firearm injuries in children.
  • Findings suggest a need for targeted outreach in rural areas and for younger children regarding firearm safety.