Related Experiment Video
Updated: Dec 13, 2025
09:01
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
14.5K
New agents in acute myeloid leukemia (AML)
Silvia Park1,2, Byung Sik Cho1,2, Hee-Je Kim1,2
1Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, Seoul, Korea.
Blood Research
|July 29, 2020
Summary
New targeted therapies offer personalized treatment for acute myeloid leukemia (AML), marking a significant shift from traditional chemotherapy. These advancements target specific molecular pathways, improving patient outcomes.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Acute myeloid leukemia (AML) treatment has remained largely unchanged for decades, relying on anthracycline and cytarabine chemotherapy.
- Despite advances in understanding AML's molecular landscape and leukemogenic pathways, novel therapeutics have been slow to emerge.
Purpose of the Study:
- To review recent therapeutic advancements in acute myeloid leukemia (AML).
- To discuss newly approved targeted agents for AML, their indications, and the rationale behind their approval.
Main Methods:
- Literature review of recent clinical trials and FDA approvals for AML therapeutics.
- Analysis of targeted agents approved since 2017.
Main Results:
- Four new FDA approvals for AML therapeutics were granted in 2017.
- A total of eight targeted agents have been approved for AML since 2017 (as of January 2020).
Conclusions:
- The treatment landscape for AML is evolving towards precision medicine, utilizing targeted agents based on individual patient molecular profiles.
- Recent approvals signify a new era of personalized therapeutic strategies for AML.
Related Concept Videos
01:15Differentiation of Common Myeloid Progenitor Cells
3.8K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.8K
01:22Bone Marrow Sampling and Transplants
713
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
713