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Spontaneous hyphema associated with ocular syphilis.

Brent Deibert1, Kellie Wark2, Rocio Diaz3

  • 1University of Nebraska Medical Center, Truhlsen Eye Institute, 3902 Leavenworth St, Omaha, NE, 68105, USA. brent.deibert@unmc.edu.

Journal of Ophthalmic Inflammation and Infection
|July 29, 2020
PubMed
Summary

Ocular syphilis can present as spontaneous hyphema, a previously unreported association. This case series highlights this novel presentation of syphilis affecting the eye.

Keywords:
HIVHyphemaNeurosyphilisOcular syphilisSyphilisUveitis

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • NeurosSyphilis

Background:

  • Ocular syphilis is a serious manifestation of syphilis infection.
  • It can affect various parts of the eye, leading to vision loss.
  • Diagnosis can be challenging due to diverse clinical presentations.

Purpose of the Study:

  • To report a novel presentation of ocular syphilis.
  • To describe two cases of ocular syphilis presenting with spontaneous hyphema.
  • To establish a potential association between ocular syphilis and spontaneous hyphema.

Main Methods:

  • Case series methodology.
  • Retrospective review of two patients with ocular syphilis.
  • Clinical examination and diagnostic workup for ocular and systemic syphilis.

Main Results:

  • Two patients presented with spontaneous hyphema.
  • Both patients were diagnosed with ocular syphilis.
  • No prior reports documented spontaneous hyphema as a presentation of ocular syphilis.

Conclusions:

  • Spontaneous hyphema can be a presenting sign of ocular syphilis.
  • This finding expands the spectrum of ocular manifestations of syphilis.
  • Increased awareness is needed to consider ocular syphilis in patients with spontaneous hyphema.