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Thawed solvent/detergent-treated plasma demonstrates comparable clinical efficacy to thawed plasma
Sabrina E Racine-Brzostek1,2, Matthew C Canver1, Robert A DeSimone1
1Department of Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medicine, New York, New York, USA.
Transfusion
|July 29, 2020
Summary
Thawed Solvent/Detergent-treated Plasma (T-S/D) is as effective as Thawed Plasma (TP) for treating coagulopathies. This study found no significant differences in transfusion outcomes or laboratory value correction between the two plasma types.
Area of Science:
- Transfusion Medicine
- Hematology
- Clinical Pathology
Background:
- Thawed Plasma (TP) is a standard transfusion product.
- Thawed Solvent/Detergent-treated Plasma (T-S/D) is a newer alternative.
- This study compares the efficacy of T-S/D to TP.
Purpose of the Study:
- To determine if T-S/D is as efficacious as TP.
- To compare T-S/D and TP in reversing coagulopathies.
- To evaluate clinical outcomes associated with T-S/D versus TP.
Main Methods:
- Retrospective cohort analysis of adult patients.
- Comparison of transfusion data between TP and T-S/D recipients.
- Primary outcome: incidence of subsequent transfusions within 24 hours.
Main Results:
- No significant difference in subsequent transfusions or blood product use.
- Similar correction of coagulation laboratory values (INR, PT/aPTT).
- T-S/D median volume transfused was 126 mL less than TP.
Conclusions:
- T-S/D is as efficacious as TP for treating coagulopathies.
- T-S/D effectively reverses coagulation laboratory values.
- T-S/D may be transfused in smaller volumes than TP.
