A theoretical mathematical model for assessing diclofenac release from chitosan-based formulations

Area of Science:

• Materials Science
• Pharmacology
• Mathematical Modeling

Background:

• Drug delivery systems are crucial for effective therapeutic outcomes.
• Understanding drug release mechanisms is essential for optimizing drug efficacy and safety.
• Chitosan-based hydrogels offer promising platforms for controlled drug delivery.

Purpose of the Study:

• To develop a new mathematical model for analyzing drug release mechanisms from polymer-drug complex systems.
• To investigate the drug release dynamics of chitosan-diclofenac systems prepared via in situ hydrogelation.
• To provide a novel pharmacokinetic behavioral analysis framework for complex drug delivery systems.

Main Methods:

• Preparation of chitosan-diclofenac sodium salt drug release systems using in situ hydrogelation.
• Characterization of system morphology using scanning electron microscopy and polarized light microscopy.
• In vitro drug release studies in a simulated physiological medium.
• Assessment of release mechanisms using traditional mathematical models and a novel multifractal approach.

Main Results:

• The study successfully prepared and characterized chitosan-diclofenac hydrogel systems.
• In vitro release data was analyzed, and a new multifractal mathematical model was proposed.
• The novel model demonstrated the synchronous dynamics of drug release at different scale resolutions within the polymer-drug complex.

Conclusions:

• A new multifractal mathematical model provides a more comprehensive understanding of drug release mechanisms in polymer-drug systems.
• The proposed model advances pharmacokinetic behavioral analysis for complex drug delivery formulations.
• This research offers a novel perspective on controlling and predicting drug release kinetics.