To Explore the Potential Targets and Current Structure-based Design Strategies Utilizing Co-crystallized Ligand to

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Heena Tarannum1, Bhumika Chauhan1, Asmita Samadder2

  • 1Department of Pharmaceutical Chemistry, Global Institute of Pharmaceutical Education and Research (Affiliated to Uttarakhand Technical University), Kashipur-244713, India.

Current Drug Targets
|July 29, 2020
PubMed
Abstract

Insights

This study explores Hepatitis C Virus (HCV) targets to understand disease progression and overcome drug resistance. Findings may aid in designing new drugs to combat chronic HCV infection.

Area of Science:

  • Virology
  • Molecular Biology
  • Drug Discovery

Background:

  • Hepatitis C Virus (HCV) is a significant global health concern, causing liver inflammation, cirrhosis, and cancer.
  • An estimated 71 million people worldwide suffer from chronic HCV infection, leading to nearly 400,000 deaths annually.
  • Drug resistance poses a major challenge in managing HCV, necessitating the exploration of novel therapeutic targets.

Purpose of the Study:

  • To investigate various HCV targets involved in disease initiation and progression.
  • To analyze the binding modes of co-crystallized ligands at the active sites of different HCV targets.

Main Methods:

  • Exploration of multiple HCV targets.
  • Analysis of ligand-target interactions through co-crystallization.
  • Focus on the binding mechanisms within the active cavities of HCV targets.

Main Results:

  • Identification of crucial ligand features that interact with amino acid residues.
  • Prediction of interactions influencing biological activity and molecular signaling.
  • Understanding of binding modes for potential therapeutic interventions.

Conclusions:

  • The study provides insights into ligand-target interactions crucial for HCV pathogenesis.
  • Identified binding modes can serve as templates for high-throughput screening.
  • This research supports the design of novel, effective anti-HCV agents to overcome drug resistance.
Keywords:
Hepatitis C virusco-crystallized liganddrug resistance in HCV targetmode of bindingstructure-based designvarious potential HCV targets

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