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Updated: Dec 13, 2025

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
[SWITCH TO MANIC EPISODE WITH MIXED FEATURES IN DEPRESSIVE SOLDIER UNDER ANTIDEPRESSANT TREATMENT]
1Department of Mental Health, Israel Defense Forces.
Introduction:
Antidepressant treatment may have some adverse clinical effects. One main effect is a switch to mania or to an affective episode with mixed features. This case report describes a young woman who developed a manic episode with mixed features, a couple of weeks following Selective Serotonin Reuptake Inhibitor (SSRI) initiation. During the episode she made a serious suicide attempt. This case report highlights the significance of clinical follow-up after antidepressant initiation.
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