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Published on: January 28, 2020
Relationship Between Platelet to Lymphocyte Ratio and Stable Coronary Artery Disease: Meta-Analysis of Observational
Zhiqiang Qiu1, Yu Jiang2, Xinghua Jiang2
1Department of Orthopedics, 47861Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Insights
The platelet to lymphocyte ratio (PLR) is elevated in patients with stable coronary artery disease (CAD). This marker may help predict the severity of CAD, including stenosis, collateral circulation, and coronary slow flow.
Area of Science:
- Cardiology
- Hematology
- Biomarkers
Background:
- Recent research suggests a link between the platelet to lymphocyte ratio (PLR) and acute coronary syndromes.
- The association between PLR and stable coronary artery disease (CAD) requires further investigation.
Purpose of the Study:
- To systematically investigate the relationship between PLR and stable CAD.
- To evaluate PLR's potential as a predictive marker for CAD severity.
Main Methods:
- A comprehensive systematic search of major electronic databases (Cochrane, PubMed, Elsevier, Medline, Embase).
- Meta-analysis of 14 studies including 4,871 participants.
- Analysis of PLR in relation to CAD presence, Gensini score, coronary collateral circulation (CCC), and coronary slow flow (CSF).
Main Results:
- Elevated PLR was significantly associated with the presence of stable CAD (P = .002).
- Higher PLR levels correlated with increased atherosclerosis severity (P < .001) and severe stenosis.
- PLR was lower in patients with good CCC (P < .001) and higher in those with CSF (P = .01).
Conclusions:
- An elevated PLR is linked to stable CAD.
- PLR may serve as a valuable predictive biomarker for CAD severity, including stenosis, collateral circulation, and CSF.
- Further research is warranted to fully elucidate the role of PLR in stable CAD.
Abstract:
Recent studies have reported a relationship between the platelet to lymphocyte ratio (PLR) and acute coronary syndromes. The aim of the present study was to investigate the association between PLR and stable coronary artery disease (CAD). A systematic search was conducted based on electronic databases (Cochrane, PubMed, Elsevier, Medline, and Embase). A total of 14 studies (n = 4,871) were included in the meta-analysis. Compared with the non-CAD group, PLR was significantly higher in CAD group (P = .002). After further classification according to the Gensini score, the cases with atherosclerosis demonstrated a higher PLR than those without atherosclerosis (P < .001). Platelet to lymphocyte ratio was higher in the severe atherosclerosis group compared with the mild atherosclerosis group (P < .001). Compared with the poor coronary collateral circulation (CCC) group, PLR was significantly lower in the good CCC group (P < .001). The PLR was significantly higher in patients with coronary slow flow (CSF) than those with normal coronary flow (P = .01). On the basis of current evidence, an elevated PLR was associated with stable CAD, and it might be useful for predicting CAD severe stenosis, collateral circulation, and CSF. Future studies are needed to clarify the relationship between PLR and stable CAD.
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