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Related Experiment Video

Updated: Jun 10, 2026

Transretinal ERG Recordings from Mouse Retina: Rod and Cone Photoresponses

Transretinal ERG Recordings from Mouse Retina: Rod and Cone Photoresponses

Published on: March 14, 2012

Stimulus-Driven Retinal Intrinsic Signal Optical Imaging in Mouse Demonstrates a Dominant Rod-Driven Component.

Momotaz Begum¹, Dorothy P Joiner¹, Daniel Y Ts'o¹

¹,.

Investigative Ophthalmology & Visual Science

|July 29, 2020

Summary

This summary is machine-generated.

Stimulus-driven optical signals in mouse retinas were observed, similar to other species. These signals require functional rod transducin, a key component of the phototransduction cascade, for their generation.

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Last Updated: Jun 10, 2026

Transretinal ERG Recordings from Mouse Retina: Rod and Cone Photoresponses

Transretinal ERG Recordings from Mouse Retina: Rod and Cone Photoresponses

Published on: March 14, 2012

Using Looming Visual Stimuli to Evaluate Mouse Vision

Using Looming Visual Stimuli to Evaluate Mouse Vision

Published on: June 13, 2019

Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

Published on: February 13, 2021

Area of Science:

Ophthalmology
Neuroscience
Physiology

Background:

Intrinsic optical signals (IOS) reflect physiological changes in tissue.
Previous studies have identified IOS in mammalian retinas, but their underlying mechanisms remain unclear.
Rod photoreceptors play a crucial role in vision, particularly in low-light conditions.

Purpose of the Study:

To investigate the existence of stimulus-driven intrinsic optical signals in the mouse retina.
To determine if these optical signals depend on the rod photoreceptor phototransduction cascade.

Main Methods:

Utilized 38 wild-type C57BL6J mice and 18 Gnat1-/- knockout mice.
Employed a custom mouse fundus camera for stimulus delivery and retinal reflectance imaging.
Stimulated retinas in the high-mesopic range with a 505-nm LED and near-infrared illumination (780 nm).

Main Results:

Wild-type mice exhibited stimulus-driven decreases in retinal reflectance (∼0.1%) with a multi-second time course.
Observed signals were spatially specific within the retina.
Gnat1-/- mice, lacking functional rod transducin, showed no stimulus-driven intrinsic optical signals.

Conclusions:

Functional rod transducin is essential for generating stimulus-driven intrinsic optical signals in the mouse retina.
These findings demonstrate in vivo mouse retinal functional imaging signals for the first time.
The results provide crucial insights into the phototransduction cascade's role in retinal optical responses.