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Updated: Dec 13, 2025
Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
Paraneoplastic vasculitis in patients with metastatic renal cell carcinoma
Ilya Tsimafeyeu1, Valentina Leonenko2, Vladimir Kuznetsov2
1Kidney Cancer Research Bureau, Moscow, Russia.
Background:
A paraneoplastic syndrome is observed in 5% to 10% of cancer patients. Paraneoplastic vasculitis (PV) in metastatic renal cell carcinoma (mRCC) patients has been poorly investigated.
Aims:
In our case series study, we evaluated the incidence and development of PV in patients with mRCC.
Methods And Results:
Patients were required to have previously untreated clear-cell or papillary mRCC and no evidence of autoimmune diseases or venous thrombosis in history. Patients had a careful examination including Doppler ultrasonography of the blood vessels and skin punch biopsy in the presence of suspicious skin rash. Sixteen (8.2%) of 196 patients were diagnosed with PV, which was manifested clinically by leukocytoclastic vasculitis on the lower extremities. Skin biopsy confirmed vasculitis. Progression-free survival and overall survival were significantly better in patients without PV.
Conclusions:
PV is not rare paraneoplastic syndrome in mRCC. Leukocytoclastic vasculitis was the most common type of PV in this study.
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