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Updated: Dec 13, 2025

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
Heterotopic Bone Formation in Clear Cell Renal Cell Carcinoma
Anirban P Mitra1, Sameer Chopra1, Saum Ghodoussipour1
1Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Abstract:
Clear cell renal cell carcinoma is associated with calcium deposition in a significant percentage of patients. However, frank ossification within a tumor is extremely rare. We report a case of a 41-year-old male with a slow-growing left renal mass who underwent minimally invasive nephron-sparing surgery. Final pathology revealed clear cell renal cell carcinoma with focal areas of heterotopic bone formation. While prognostic implications of this variant are unclear, patients with renal cell carcinoma with osseous metaplasia can present with slow growth kinetics and early-stage disease.
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