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Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
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Rising from the ashes: cellular senescence in regeneration
Hannah E Walters1, Maximina H Yun2
1CRTD/DFG-Center for Regenerative Therapies Dresden (Cluster of Excellence), TU Dresden, Germany.
Current Opinion in Genetics & Development
|July 30, 2020
Summary
Cellular senescence, a state of irreversible cell cycle arrest, has dual roles. While implicated in aging, it also supports development, tumor suppression, and tissue repair through beneficial non-cell-autonomous effects.
Area of Science:
- Cellular and Molecular Biology
- Gerontology
- Developmental Biology
Background:
- Cellular senescence is increasingly linked to aging pathologies.
- Current research focuses on senolytic agents to eliminate senescent cells.
- Senescence also has crucial physiological functions.
Purpose of the Study:
- To analyze the beneficial roles of cellular senescence.
- To understand senescence's involvement in physiological processes.
- To inform strategies for aging and disease.
Main Methods:
- Review of recent evidence on senescence.
- Analysis of non-cell-autonomous effects of senescence.
- Exploration of senescence's role in tissue remodeling and regeneration.
Main Results:
- Senescence plays roles in development, tumor suppression, and fibrosis limitation.
- Transient senescence can facilitate tissue remodeling and regeneration.
- Non-cell-autonomous effects include promoting proliferation, plasticity, and immune interactions.
Conclusions:
- Cellular senescence has beneficial physiological roles beyond its association with aging.
- Understanding these beneficial aspects can guide therapeutic strategies.
- Further research into senescence's positive functions is warranted for health and disease insights.
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