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Related Experiment Video

Updated: Dec 13, 2025

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Multiphase flow in microfluidics: From droplets and bubbles to the encapsulated structures.

Amirmohammad Sattari1, Pedram Hanafizadeh2, Mina Hoorfar3

  • 1School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran; School of Engineering, University of British Columbia, Kelowna, BC, Canada.

Advances in Colloid and Interface Science
|July 30, 2020
PubMed
Summary

Microfluidic devices offer precise control over two-phase flows, enabling advancements in droplet and bubble manipulation. This technology is crucial for applications in drug delivery, biotechnology, and microreactors.

Keywords:
EncapsulationLab-on-a-chipMicrofluidicMultiphaseTwo-phase-flow

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Area of Science:

  • Fluid dynamics
  • Microfluidics
  • Chemical Engineering

Background:

  • Microfluidic systems provide superior control over two-phase flows compared to macroscale systems.
  • Precise control over droplet and bubble size is a key driver for microfluidic technology expansion.
  • Liquid-liquid and gas-liquid two-phase flows are critical in microfluidics due to diverse applications.

Purpose of the Study:

  • To review recent advancements in microfluidic two-phase flow systems.
  • To provide a comprehensive overview of fundamental principles and production methods.
  • To highlight key applications of these systems.

Main Methods:

  • Introduction to the fundamentals of two-phase flows, including dimensionless numbers and governing equations.
  • Review of standard methods for producing segmented flows, such as emulsions.
  • Discussion of various encapsulated structures and their production techniques.

Main Results:

  • Microfluidics enables enhanced control over droplet and bubble formation in two-phase systems.
  • Established methods for generating emulsions and encapsulated structures within microfluidic devices.
  • Identified critical parameters and numerical methods for analyzing microfluidic two-phase flows.

Conclusions:

  • Microfluidic technology is pivotal for precise manipulation of two-phase flows.
  • The review covers fundamental principles, production methods, and diverse applications.
  • Significant potential exists for microfluidic two-phase flows in drug delivery, biotechnology, and microreactors.