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Common and distinct functional stability abnormalities across three major psychiatric disorders
Jiajia Zhu1, Shujun Zhang1, Huanhuan Cai1
1Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Neuroimage. Clinical
|July 30, 2020
Summary
This study reveals distinct brain functional stability patterns in schizophrenia and bipolar disorder, highlighting shared abnormalities in the inferior temporal gyrus and unique changes in schizophrenia. ADHD showed no significant differences from controls.
Area of Science:
- Neuroscience
- Psychiatry
- Neuroimaging
Background:
- Understanding shared and distinct neuropathological characteristics across psychiatric disorders is crucial for their pathophysiology.
- Dynamic functional connectivity offers a novel approach to assess brain function over time.
Purpose of the Study:
- To investigate common and distinct brain functional abnormalities across psychiatric disorders using functional stability.
- To explore the utility of functional stability as a biomarker in psychiatric research.
Main Methods:
- Resting-state functional magnetic resonance imaging (fMRI) data were acquired from healthy controls (n=115) and individuals with schizophrenia (SZ, n=47), bipolar disorder (BD, n=44), and attention deficit/hyperactivity disorder (ADHD, n=40).
- Functional stability was calculated by measuring the temporal concordance of dynamic functional connectivity.
- Voxel-wise analyses were performed to compare functional stability across the four groups.
Main Results:
- Individuals with schizophrenia exhibited widespread higher functional stability in the inferior temporal gyrus and lower stability in the calcarine sulcus and insula compared to controls.
- Individuals with bipolar disorder showed localized higher functional stability in the left inferior temporal gyrus.
- Schizophrenia and bipolar disorder shared increased functional stability in the left inferior temporal gyrus; schizophrenia uniquely showed increased stability in the right inferior temporal gyrus and decreased stability in the calcarine sulcus and insula.
Conclusions:
- Functional stability analysis reveals both shared and disorder-specific alterations in brain connectivity across psychiatric conditions.
- The findings support the potential of functional stability as a valuable tool for psychiatric research and understanding transdiagnostic neuropathology.
- Further research is warranted to explore the clinical implications and diagnostic utility of functional stability.
Keywords:
Dynamic functional connectivityFunctional MRIFunctional stabilityPsychiatric disordersResting stateMore Related Videos
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