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Author Spotlight: Gut Microbiome-Lung Tissue Communication Through Short-Chain Fatty Acid Analysis
Published on: June 21, 2024
Gut Microbiome and AKI: Roles of the Immune System and Short-Chain Fatty Acids
Sepideh Gharaie1, Sanjeev Noel1, Hamid Rabb2
1Division of Nephrology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Abstract:
Acute kidney injury (AKI) is a common and serious syndrome that involves multiple pathophysiologic mechanisms. Recent studies have demonstrated that dysbiosis of the gut microbiota mediates experimental AKI. The precise microbial populations involved and the underlying mechanisms are currently being explored. In this mini-review based on the NIH AKI O'Brien Center symposium of February 2020, we discuss data on gut microbiota in AKI with a focus on the immune system and short-chain fatty acids as mediators of microbiome-kidney crosstalk.
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