Headache and Osmophobia in Gas Station Workers Exposed to Gasoline Odor

Headache attacks may be triggered by several factors, among them odors, especially in migraine patients.

The aim of this study wasto determine the association between gasoline odor and headache attacks in patients with migraine or tension-type headache (TTH).

The study was prospective, cross-sectional, with comparison of groups, using nonrandom sample and convenience. Fifty-two gas station workers diagnosed with migraine or TTH according to ICHD-3 criteria were interviewed on the relationship between gasoline odor and headache.

Of the 52 gas station workers with headaches, there were 39 (75%) with migraine without aura and 13 (25%) with TTH. The age ranged from 19 to 50 years, with a mean of 29.5 ± 7.2 years. Osmophobia during headache attacks predominated in workers with migraine (29/39; 74.4%). The onset of headache due to odor exposure occurred in 23/39 (60%) of the workers with migraine and in 2/13 (15.4%) in TTH. These differences were statistically significant (χ2 = 7.4; p = 0.016). Osmophobia in the absence of pain (period between attacks) predominated in workers with migraine (17/39, 43.6%), but with no statistical value.

Gas station workers diagnosed with migraine or TTH may experience osmophobia and headache triggered by the odor of gasoline.