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Hyperuricemia Is Associated with Left Ventricular Dysfunction and Inappropriate Left Ventricular Mass in Chronic
Tai-Hua Chiu1, Pei-Yu Wu2,3,4, Jiun-Chi Huang2,3,4
1Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Insights
High serum uric acid (UA) is linked to adverse echocardiographic changes in chronic kidney disease (CKD) patients. These findings suggest UA may impact cardiovascular health in CKD.
Area of Science:
- Nephrology
- Cardiology
- Biochemistry
Background:
- Hyperuricemia is prevalent in chronic kidney disease (CKD) patients.
- Elevated serum uric acid (UA) is associated with poor cardiovascular outcomes.
Purpose of the Study:
- To investigate the relationship between serum UA levels and echocardiographic parameters.
- To assess associations with ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in CKD patients.
Main Methods:
- Cross-sectional study of 418 patients with CKD.
- Echocardiographic measurements included left atrial diameter (LAD), left ventricular ejection fraction (LVEF), and left ventricular mass (LVM).
- ABI and baPWV were also assessed.
Main Results:
- High UA levels significantly correlated with increased LAD, higher LVM, and reduced LVEF.
- No significant associations were found between UA and ABI or baPWV.
- Multivariable analysis confirmed UA's association with abnormal echocardiographic findings.
Conclusions:
- Elevated serum UA is associated with adverse echocardiographic parameters in CKD patients.
- High UA may contribute to cardiac abnormalities in stages 3-5 CKD.
Background:
Hyperuricemia is common in patients with chronic kidney disease (CKD), and this may lead to poor cardiovascular (CV) outcomes. The aim of this cross-sectional study was to assess associations among serum uric acid (UA) and echocardiographic parameters, ankle-brachial index (ABI), and brachial-ankle pulse wave velocity (baPWV) in patients with CKD.
Methods:
A total of 418 patients with CKD were included. The echocardiographic measurements included left atrial diameter (LAD), left ventricular ejection fraction (LVEF) and the ratio of observed to predict left ventricular mass (LVM). ABI, baPWV and medical records were obtained.
Results:
Multivariable forward logistic regression analysis showed that a high UA level was significantly associated with LAD > 47 mm (odds ratio [OR], 1.329; p = 0.002), observed/predicted LVM > 128% (OR, 1.198; p = 0.008) and LVEF < 50% (OR, 1.316; p = 0.002). No significant associations were found between UA and ABI < 0.9 or baPWV > 1822 cm/s. Multivariate stepwise linear regression analysis showed that a high UA level correlated with high LAD (unstandardized coefficient β, 0.767; p < 0.001), high observed/predicted LVM (unstandardized coefficient β, 4.791; p < 0.001) and low LVEF (unstandardized coefficient β, -1.126; p = 0.001). No significant associations between UA and low ABI and high baPWV were found.
Conclusion:
A high serum UA level was associated with a high LAD, high observed/predicted LVM and low LVEF in the patients with CKD. A high serum UA level may be correlated with abnormal echocardiographic parameters in patients with stage 3-5 CKD.
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