Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction.

Nature communications·2025

Same author

Extra-pineal melatonin in perisynaptic Schwann cell-muscle fiber cross talk at the regenerating neuromuscular junction.

Neural regeneration research·2025

Same author

Hydrogen Peroxide Modulates the Timely Activation of Jun and Erk in Schwann Cells at the Injury Site and Is Required for Motor Axon Regeneration.

Cells·2025

Same author

Twenty-one days of bed rest alter motor unit properties and neuromuscular junction transmission in young adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2025

Same author

Neuromuscular junction instability with inactivity: morphological and functional changes after 10 days of bed rest in older adults.

The Journal of physiology·2025

Same author

Schwann Cell-Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024

Same journal

RETRACTED: Bakshi et al. Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways. <i>Cells</i> 2022, <i>11</i>, 1502.

Cells·2026

Same journal

Correction: Verde et al. Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses. <i>Cells</i> 2025, <i>14</i>, 680.

Cells·2026

Same journal

Inflammation in Cardiomyopathies: Cellular Mechanisms Across Cardiac Phenotype.

Cells·2026

Same journal

IL-4/IL-13-Driven Dysregulation of Epidermal Lipid Metabolism in Atopic Dermatitis: An Immunometabolic Link Between Type 2 Inflammation and Barrier Dysfunction.

Cells·2026

Same journal

Activity of DNA- and RNA-Guided Prokaryotic Argonautes in Human Mitochondria.

Cells·2026

Same journal

Placental Pathophysiology in Maternal Psychoactive Substance Use: Biological, Clinical, and Forensic Perspectives.

Cells·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 13, 2025

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Published on: May 3, 2024

Signals Orchestrating Peripheral Nerve Repair.

Michela Rigoni^1,2, Samuele Negro¹

¹Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.

|July 30, 2020

Summary

This summary is machine-generated.

Peripheral nerve regeneration involves intrinsic neuronal abilities and a supportive environment, with Schwann cells coordinating signals for axon regrowth after injury.

Keywords:

Schwann cells cell signaling neurodegeneration neuromuscular junction neuroregeneration

More Related Videos

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Related Experiment Videos

Last Updated: Dec 13, 2025

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Published on: May 3, 2024

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Area of Science:

Neuroscience
Cell Biology
Regenerative Medicine

Background:

The peripheral nervous system (PNS) possesses a remarkable capacity for repair and regeneration following injury.
Nerve regeneration is a complex process involving intrinsic neuronal factors and extrinsic environmental cues.

Purpose of the Study:

To review intrinsic and extrinsic mechanisms governing peripheral nerve axon regrowth.
To discuss key signaling molecules and pathways involved in nerve regeneration.
To highlight the role of Schwann cells and the neuromuscular junction in this process.

Main Methods:

Literature review of studies on peripheral nerve regeneration.
Analysis of intrinsic neuronal and extrinsic environmental factors.
Focus on signaling pathways, alarm mediators, and pro-regenerative molecules.

Main Results:

Peripheral nerve regeneration depends on neuronal intrinsic growth capacity and a permissive extracellular environment.
Schwann cells act as central coordinators, integrating signals from various components like neurons, muscles, and the immune system.
Specific molecules and pathways, including alarm mediators and pro-regenerative factors, are crucial for successful axon regrowth.

Conclusions:

Understanding the interplay of intrinsic and extrinsic factors is key to promoting peripheral nerve repair.
The neuromuscular junction serves as a valuable model for identifying critical mediators of nerve regeneration.
Further research into these mechanisms can lead to improved therapeutic strategies for nerve injuries.