Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatic SMARCA4 predicts HCC recurrence and promotes tumour cell proliferation by regulating SMAD6 expression.

Cell death & disease·2018
Same author

Determination of phthalate esters in soil using a quick, easy, cheap, effective, rugged, and safe method followed by GC-MS.

Journal of separation science·2018
Same author

PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation.

Stem cell research·2018
Same author

Downregulation of gasdermin D promotes gastric cancer proliferation by regulating cell cycle-related proteins.

Journal of digestive diseases·2018
Same author

An Artificial Flexible Visual Memory System Based on an UV-Motivated Memristor.

Advanced materials (Deerfield Beach, Fla.)·2018
Same author

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice.

Journal of hepatology·2017

Related Experiment Video

Updated: Dec 13, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.6K

Human L1 Transposition Dynamics Unraveled with Functional Data Analysis.

Di Chen1, Marzia A Cremona2,3, Zongtai Qi4

  • 1Intercollege Graduate Degree Program in Genetics, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA.

Molecular Biology and Evolution
|July 30, 2020
PubMed
Summary

Long Interspersed Elements-1 (L1s) preferentially integrate into open chromatin but are fixed in gene-poor regions. L1 insertions can alter local genomic features like methylation and microsatellites.

Keywords:
LINE-1fixationintegrationtransposable elementstransposition

More Related Videos

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.4K
Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound fTCD
07:44

Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound fTCD

Published on: September 27, 2010

20.7K

Related Experiment Videos

Last Updated: Dec 13, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.6K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.4K
Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound fTCD
07:44

Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound fTCD

Published on: September 27, 2010

20.7K

Area of Science:

  • Genomics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Long Interspersed Elements-1 (L1s) are mobile genetic elements comprising over 17% of the human genome.
  • L1 transposition is crucial for understanding genome evolution and somatic mutations, but insertion and fixation patterns remain incompletely characterized.
  • Comprehensive analysis of L1 genomic patterns is needed to elucidate their role in genome dynamics.

Purpose of the Study:

  • To investigate and characterize genome-wide insertion and fixation patterns of L1 elements at different evolutionary stages.
  • To identify genomic features associated with L1 integration and fixation across various L1 datasets.
  • To develop an integrative model explaining L1 transposition preferences and their genomic impact.

Main Methods:

  • Utilized three genome-wide datasets: de novo L1s (experimental), polymorphic L1s (public), and human-specific L1s (public).
  • Characterized 49 genomic features within ±50kb flanks of L1 elements, including chromatin accessibility, transcriptional activity, and replication.
  • Applied Functional Data Analysis to contrast genomic features between L1 datasets and L1-free regions.

Main Results:

  • Distinct genomic features surround de novo, polymorphic, and human-specific L1s at specific locations and scales.
  • L1s preferentially integrate into open chromatin with non-B DNA motifs and are fixed in regions under low purifying selection (gene-poor, low conservation).
  • L1 insertions appear to modify the local genome by increasing CpG methylation and mononucleotide microsatellite density.

Conclusions:

  • Established an integrative model for L1 transposition, detailing integration and fixation preferences.
  • Findings enhance understanding of L1 roles in genome evolution, somatic mutations, aging, and cancer.
  • Provides insights into L1s as potential mutagenesis tools in genetic research.