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Engineering Anisotropic Meniscus: Zonal Functionality and Spatiotemporal Drug Delivery.

Anna Abbadessa1,2, José Crecente-Campo1,2, María José Alonso1,2

  • 1Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), IDIS Research Institute, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

Tissue Engineering. Part B, Reviews
|July 30, 2020
PubMed
Summary

Regenerating knee meniscus tissue requires advanced drug delivery (DD) and tissue engineering (TE) strategies. Combining these approaches can restore meniscus function and address osteoarthritis risk after injury.

Keywords:
anisotropic tissue regenerationdrug deliverygrowth factorsmeniscustissue engineeringzonal reconstruction

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedics

Background:

  • Meniscus degeneration leads to knee osteoarthritis and reduced mobility.
  • Current treatments like meniscectomy have limitations in restoring meniscus function.
  • There is a need for innovative strategies to regenerate functional meniscus tissue.

Purpose of the Study:

  • To critically review spatiotemporal drug delivery (DD) and tissue engineering (TE) strategies for meniscus regeneration.
  • To discuss the importance of zonal differentiation in meniscal tissue implants.
  • To explore the combination of DD and TE for multizonal meniscal reconstruction.

Main Methods:

  • Review of current literature on drug delivery systems for growth factor release.
  • Analysis of tissue engineering approaches mimicking meniscus anisotropy.
  • Discussion of synergistic strategies combining DD and TE.

Main Results:

  • Drug delivery systems offer controlled release of bioactive molecules.
  • Tissue engineering strategies focus on replicating the native meniscus's anisotropic structure.
  • Combined DD and TE approaches show promise for functional meniscus regeneration.

Conclusions:

  • Advanced drug delivery and tissue engineering are crucial for meniscus regeneration.
  • Mimicking the zonal differentiation and anisotropic structure of the meniscus is key.
  • Synergistic DD and TE strategies are expected to drive future advancements in meniscus repair.