Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.1K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

866
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
866
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.0K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Online toxic speech as positioning acts: Hate as discursive mechanisms for othering and belonging.

New media & society·2026
Same author

Outcomes of the Paul Glaucoma Implant in an Ambispective Multicenter Study: 12-Month Follow-Up.

Biomedicines·2026
Same author

Impact of visit schedule on estimated success rates in glaucoma surgical studies.

The British journal of ophthalmology·2026
Same author

A vision transformer model for the detection of glaucoma from optic disc photographs.

Scientific reports·2026
Same author

Detection of Structural Glaucoma Progression with Deep Learning on Serial Optic Disc Photographs.

Ophthalmology. Glaucoma·2026
Same author

The Incidence of Clinically Significant Hypotony After Trabeculectomy.

Journal of glaucoma·2026

Related Experiment Video

Updated: Dec 13, 2025

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.4K

The Trajectory of Glaucoma Progression in 2-Dimensional Structural-Functional Space.

Agustina de Gainza1, Esteban Morales1, Diana C Salazar Vega1

  • 1Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

Ophthalmology. Glaucoma
|July 30, 2020
PubMed
Summary

This study introduces a new method to visualize glaucoma progression using structural and functional changes in 2D space. The trajectory slope indicates disease severity, aiding in understanding glaucoma development.

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.7K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.7K

Related Experiment Videos

Last Updated: Dec 13, 2025

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.4K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.7K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.7K

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma is a progressive optic neuropathy characterized by structural and functional damage.
  • Visualizing the trajectory of glaucoma progression is crucial for effective management.
  • Current methods may not fully capture the combined structural-functional decline over time.

Purpose of the Study:

  • To present a novel method for visualizing structural and functional changes in glaucoma progression within a 2-dimensional space.
  • To develop a tool that integrates structural and functional data to represent disease trajectory.

Main Methods:

  • A retrospective, longitudinal observational study using data from the Stein Eye Institute, UCLA (1993-2017).
  • Two cohorts were used: Cohort 1 for developing structural and functional scores, and Cohort 2 for applying these scores.
  • Structural scores were derived from Heidelberg Retina Tomograph data, and functional scores from visual field (VF) index, creating a structural-functional (S-F) 2D space.

Main Results:

  • 290 vectors representing glaucoma progression trajectories were generated from 290 eyes.
  • The mean follow-up period was 14.6 years.
  • Mean vector slopes increased with disease severity, indicating faster progression in more advanced glaucoma stages.

Conclusions:

  • A method to visualize glaucoma progression trajectory in 2D S-F space has been established.
  • The slope of this trajectory is directly related to the severity of the glaucoma.
  • This visualization method offers a new perspective on understanding and monitoring glaucoma progression.