Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

39.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.3K
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

1.7K
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
1.7K
Biostatistics: Overview01:20

Biostatistics: Overview

617
Biostatistics plays a crucial role in understanding and analyzing data in healthcare and biology. Biostatisticians conduct experiments, gather evidence, and draw meaningful conclusions using statistical methods and techniques. Different variables form the foundation of biostatistical analysis, allowing researchers to understand and interpret data effectively. These variables are classified into different types, each serving a specific purpose in statistical analysis.
Discrete variables are...
617
Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs01:21

Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs

2.8K
The fundamental mathematical principles, such as calculus and graphs, play crucial roles in analyzing drug movement and determining pharmacokinetic parameters. Differential calculus examines rates of change and helps to determine the dissolution rate of drugs in biofluids, as well as how drug concentrations change over time. For instance, it can help calculate the rate of elimination of a drug from the body based on its concentration-time profile.
On the other hand, integral calculus focuses on...
2.8K
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

200
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
200
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

6.0K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The moderating role of HIV status in the association between gender identity and depression among sexual and gender minorities in Abuja, Nigeria.

PLOS mental health·2026
Same author

Intravenous injection of lipid-free apolipoprotein A-I dampens inflammation by reprogramming macrophage function.

Cell reports·2026
Same author

RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR.

Cell death and differentiation·2026
Same author

Within session reliability of center of pressure measures to assess lower limb postural control under alternative auditory conditions.

Gait & posture·2026
Same author

Brief Report: The Trials of Insurance-Based Data to Care-Rx: Low Enrollment in the Antiretroviral Improvement Among Medicaid EnrolleeS (AIMS) Study.

Journal of acquired immune deficiency syndromes (1999)·2026
Same author

Modified Star Excursion Balance Test Performance in Individuals With Chronic Ankle Instability: A Participant-Level Analysis.

Journal of foot and ankle research·2026
Same journal

Clarifying the relationship between biomedical and health informatics and digital health: expert perspectives.

BMJ health & care informatics·2026
Same journal

Measuring performance trajectories in lung cancer surgery: a longitudinal study using the French national hospital database from 2020 to 2024.

BMJ health & care informatics·2026
Same journal

Mapping of mental health indicators in the WHO European region: a scoping review.

BMJ health & care informatics·2026
Same journal

Automated monitoring in clinical and operational workflows.

BMJ health & care informatics·2026
Same journal

Characterising 'Watch and Wait' prescribing patterns in paediatric otitis media using large language models and pharmacy dispense data.

BMJ health & care informatics·2026
Same journal

Alzheimer's disease risk prediction from clinical and social determinants of health: a machine learning cohort study in UK Biobank.

BMJ health & care informatics·2026
See all related articles

Related Experiment Video

Updated: Dec 13, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.1K

A NICE perspective on computable biomedical knowledge.

Andrew Mitchell1

  • 1National Institute for Health and Care Excellence, Manchester, Greater Manchester, UK andrew.mitchell@nice.org.uk.

BMJ Health & Care Informatics
|July 30, 2020
PubMed
Summary
This summary is machine-generated.

The National Institute for Health and Care Excellence (NICE) aims to enhance decision-making by moving towards computable knowledge products. This initiative, NICE Connect, aligns with the NHS Long Term Plan for improved interoperability and learning health systems.

Keywords:
health careinformation management

More Related Videos

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

2.0K
Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

5.2K

Related Experiment Videos

Last Updated: Dec 13, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.1K
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

2.0K
Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

5.2K

Area of Science:

  • Health informatics
  • Knowledge management in healthcare
  • Evidence-based practice

Background:

  • The National Institute for Health and Care Excellence (NICE) is pivotal in disseminating best practices within the NHS.
  • NICE aims to improve healthcare decision-making and patient outcomes through evidence-based recommendations.
  • Understanding computable knowledge is crucial for developing learning health systems.

Purpose of the Study:

  • To review NICE's current products and services using the Agency for Healthcare Research and Quality (AHRQ) knowledge hierarchy.
  • To envision the evolution of NICE's offerings towards more structured and computable knowledge.
  • To align NICE's strategic initiatives with national health system goals for interoperability.

Main Methods:

  • Utilized the AHRQ 4 levels of knowledge as a framework for analysis.
  • Reviewed existing NICE products and services.
  • Envisioned future development pathways for NICE's knowledge dissemination.

Main Results:

  • NICE currently operates primarily at Level 1 of the AHRQ knowledge hierarchy.
  • There is an aspiration to transition towards structured and computable knowledge products.
  • The NHS Long Term Plan emphasizes interoperability and data exchange standards.

Conclusions:

  • NICE Connect represents NICE's strategic ambition to adapt to technological advancements and evolving system needs.
  • Alignment between NICE Connect and the Mobilising Computable Biomedical Knowledge (MCBK) agenda is essential for success.
  • The initiative aims to ensure sustainable and efficient management of NICE's guidance portfolio.