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Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
09:37

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Diastolic dysfunction in patients with liver cirrhosis: A short-term, observational study at a Malaysian hospital

K A Abdul Aziz1, N Draman2, W Y H Wan Isa3

  • 1Hospital Teluk Intan, Department of Medicine, Jalan Changkat Jong, Teluk Intan, Perak, Malaysia.

The Medical Journal of Malaysia
|July 30, 2020
PubMed

Insights

Diastolic dysfunction is common in liver cirrhosis patients, even with early disease stages. Higher age and sodium levels are linked to this condition, highlighting the need for sodium restriction.

Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Cirrhotic cardiomyopathy is a known complication of liver cirrhosis.
  • It is associated with poor patient outcomes.
  • Diastolic dysfunction is an early indicator of left ventricular dysfunction.

Purpose of the Study:

  • To determine the prevalence of diastolic dysfunction in liver cirrhosis patients.
  • To identify factors associated with diastolic dysfunction in this population.

Main Methods:

  • The study involved patients with liver cirrhosis attending an outpatient clinic.
  • Echocardiography was likely used for diastolic function assessment (implied).
  • Multiple regression analysis was employed to identify associated factors.

Main Results:

  • A high prevalence of diastolic dysfunction was observed in liver cirrhosis patients.
  • The majority of affected patients were Child-Pugh A/low MELD score, indicating early disease stages.
  • Age and serum sodium levels were significantly associated with diastolic dysfunction.

Conclusions:

  • Diastolic dysfunction is prevalent in liver cirrhosis, including early stages.
  • Age and sodium levels are key factors associated with diastolic dysfunction.
  • Dietary sodium restriction is crucial for managing liver cirrhosis patients to mitigate cardiac complications.

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